NFL football pool, pick’em, office pool, confidence picks: Back the Cardinals for Week 2, 2021

The 2021 NFL season got off to a scintillating start with Buccaneers vs. Cowboys coming down to a field goal as time expired and eight other games being decided by a single possession. That level of parity could present a challenge for your NFL office pool picks, and the Week 2 NFL schedule will present a number of head scratchers as well. The Cowboys will hope to build on a strong performance in a loss to the defending champions, but are three-point road underdogs against the Chargers in the Week 2 NFL odds.

Can Dak Prescott keep the Cowboys’ offense rolling? That’s just one of many tough calls as you make your Week 2 NFL confidence pool picks. Before you make your NFL predictions, you need to see the Week 2 NFL football pool picks from SportsLine’s proven model.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters the 2021 season on an incredible 120-78 run on top-rated NFL picks that dates back to the 2017 season.

More importantly for NFL confidence pool players, the model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports office pool players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated the entire Week 2 2021 NFL schedule 10,000 times and generated its optimal NFL pick’em plays. Go to SportsLine to see them.

Top Week 2 NFL office pool predictions

One of the top Week 2 NFL pick’em predictions from the model: Arizona cruises past Minnesota and gets a comfortable win at home as a 4.5-point favorite. The Cardinals are coming off an impressive demolition of the Titans in Week 1, while Minnesota lost in overtime to the Bengals.

Kyler Murray got his third season in the NFL off to a stellar start by going 21-of-32 for 289 yards and four touchdowns, adding a fifth touchdown with his legs. Murray could have his way with a Vikings defense that let Joe Burrow go 20-of-27 for 261 yards and two scores last week and had problems covering Ja’Marr Chase, as the rookie had five catches for 101 yards and two scores in his debut.

Despite Chase’s immense upside, DeAndre Hopkins is a far bigger threat to a secondary and had two highlight-reel touchdowns in Week 1. Hopkins finished with six catches for 83 yards and those two scores, and the model likes him to catch eight passes for 98 yards and another score on Sunday. That’s a big reason why the Cardinals win in well over 60 percent of simulations and cover well over 50 percent of the time with a projected final score of 30-22.

How to make Week 2 NFL office pool picks

The model also made the call on every other Week 2 game and has strong picks for potentially close matchups like Chiefs vs. Ravens and Rams vs. Colts. It’s also calling for a Super Bowl contender to go down hard. You can only see all of the model’s NFL pool picks here.

So who should you pick in every Week 2 NFL game? And which Super Bowl favorite goes down hard? Visit SportsLine now to get optimal NFL office pool picks, all from the advanced computer model that has ranked in the Top 10 on straight-up picks four of the last five years and went an outstanding 121-79 on top-ranked picks since 2017 .

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